Development Optimization and Evaluation of Fast Disintegrating Tablets of Antiepileptic Drug Carbamazepine

Background: The main objective of present research work is to formulate the Carbamazepine as Fast Disintegrating tablets give fast relief and an increase in patient compliance. Carbamazepine, antiepileptic, belongs BCS Class-II used control some types seizures treatment epilepsy Neuropathic Pain by blocking use-dependent sodium channels.
 Methods: powdered materials were compressed direct compression technique using super disintegrants like starch glycollate, croscarmellose starch, Magnesium Stearate Di Calcium Phosphate are lubricant diluents/fillers respectively.
 Result Discussion: Totally nine formulations designed evaluated for hardness, friability, thickness, assay, wetting time, Disintegration in-vitro drug release. From Results concluded that all formulation found be with Pharmacopeial limits In-vitro dissolution profiles fitted different Kinetic models, statistical parameters intercept (a), slope (b) & regression coefficient (r) calculated. optimized was characterized help Differential Scanning Calorimetry (DSC), Fourier Transform Infrared Spectroscopy (FTIR) studies show no interaction between excipients. stability study conducted per ICH guidelines stable, insignificant changes content disintegration time.
 Conclusion: These results revealed disintegrating poorly soluble drug, carbamazepine, showing enhanced and, hence, better